Kayayyaki
2,6-Di-tert-butyl-4-methylpyridine
Tsarin Tsari
Bayyanar: farin acicular crystal
Girma: 1,476 g/cm3
Matsayin narkewa: 31-32 ℃
Matsayin tafasa: 148-153 ℃ (12.6kPa)
Fihirisar magana: N20/D 1.4763(lit.)
Wutar walƙiya: 183 °F
Yanayin ajiya: 2-8°C
Ƙimar acidity (pKa): 6.88± 0.10 (An annabta)
Bayanan Tsaro
Nasa ne da kaya na gaba ɗaya
Lambar Kwastam: 2942000000
Yawan rangwamen haraji na fitarwa (%): 13%
Aikace-aikace
Matsakaici na roba na halitta, mai hanawa, wanda ba na nucleophilic tushe wanda ya bambanta tsakanin Brnsted (protonic) da Lewis acid.Yana ba da damar jujjuya babban amfanin kai tsaye na aldehydes1 da ketones1,2 zuwa vinyl triflates.
2,6-Di-tert-butyl-4-methylpyridine wani nau'i ne na kwayoyin halitta tare da tsarin kwayoyin C14H23N, wani muhimmin tsaka-tsaki a cikin tsarin kwayoyin halitta, wanda aka fi amfani dashi a cikin magungunan magunguna, kwayoyin halitta, magungunan kwayoyin halitta, kuma ana iya amfani dashi a cikin samar da rini, magungunan kashe qwari. samarwa da kamshi, da dai sauransu.
Hanyar samarwa
1. Yi 2,6 di-tert-butyl-4-methylbenzyl trifluoromethanesulfonate A cikin 100-mL flask sau uku sanye take da bututun gabatarwar nitrogen, mazugi na matsewa akai-akai, mashaya mai motsi na lantarki da na'urar kwandon kankara tare da busassun bututu, ƙara 24.2 g (0.2 mol) na trimethylethyl phthalide chloride da 3.7 g (0.05 mol) na tert-butanol.An ɗora cakuda maganin a cikin wanka mai mai zuwa 85 ° C.Sa'an nan kuma an ƙara 15 g (0.1 mol) na trifluoromethanesulfonic acid fiye da minti 15.An ci gaba da amsawa na minti 10, kuma an sanyaya samfurin samfurin launin ruwan kasa a cikin wanka na kankara kuma an zuba shi cikin 100 ml na ether mai sanyi.An tace hazo mai launin ruwan kasa kuma an bushe don samun 9.6 g (54%) na jinkirin gishiri.(Ba a buƙatar tsarkakewa: don mataki na gaba na shirye-shiryen, sake yin recrystallize sau biyu daga chloroform zuwa carbon tetrachloride 3: 1) zuwa lu'ulu'u marasa launi-kamar allura.
2. Shirye-shiryen 2,6-Di-tert-butyl-4-methyl-vizine A ƙarƙashin motsawa, dakatar da 10 g (0.028 mol) na danyen gishiri na vizine a cikin 200 ml na 95% ethanol mai sanyi zuwa 60 ° C. ƙara sau ɗaya zuwa 100 ml na ammonia mai daɗaɗɗen sanyi mai sanyi zuwa 60 ° C a cikin kwalban lambun-lita 1 na ƙasa.An ci gaba da amsawa a 60 ° C na minti 30 da 40 ° C na tsawon sa'o'i 2, lokacin da aka narkar da dakatarwar.Sa'an nan, da dauki cakuda da aka zuba a cikin 500 ml na 2% sodium hydroxide bayani a hankali warmed zuwa dakin zafin jiki.Cire tare da .4-100 ml na pentane, haɗe-haɗe, 25 ml na cikakken bayani sodium chloride wanke, 100 ml na pentane rotary evaporator maida hankali.
