Kayayyaki
5-Fluorocytosine
Tsarin Tsari
Na zahiri
Bayyanar: Farin foda
Yawan yawa: 1.3990 (kimanta)
Matsakaicin narkewa: 298-300 °C (dic.) (lit.)
Wurin tafasa.
Refractivity
Ma'anar walƙiya.
Bayanan Tsaro
Kashi mai haɗari.
Lambar safarar Kaya mai haɗari.
Kashi na shiryawa.
Aikace-aikace
Ana amfani da Flucytosine ta baki don maganin cututtuka masu tsanani da ke haifar da cututtuka na Candida ko Cryptococcus neoformans.Hakanan za'a iya amfani da shi don maganin chromomycosis (chromoblastomycosis), idan nau'i mai sauƙi yana haifar da kamuwa da cuta.Ba dole ba ne a yi amfani da Flucytosine a matsayin wakili na musamman a cikin cututtukan fungal masu barazana ga rayuwa saboda ingantacciyar tasirin antifungal mai rauni da saurin haɓaka juriya, amma a hade tare da amphotericin B da / ko azole antifungals kamar fluconazole ko itraconazole.Ƙananan cututtuka irin su candidal cystitis za a iya bi da su tare da flucytosine kadai.A wasu ƙasashe, jiyya tare da jinkirin jiko na cikin jini wanda bai wuce mako guda ba shima zaɓi ne na warkewa, musamman idan cutar tana da haɗari ga rayuwa.
Mummunan cututtuka na fungal na iya faruwa a cikin waɗanda ba su da rigakafi.Wadannan mutane suna amfana daga hanyoyin haɗin gwiwa ciki har da flucytosine, amma abubuwan da ke haifar da illa na haɗin gwiwa, musamman tare da amphotericin B, na iya zama mafi girma.
5-Fluorocytosine ana amfani da shi wajen magance cututtukan fungal da Cryptococcus da Candida ke haifarwa, kamar su fungal sepsis, endocarditis, meningitis, da magungunan antifungal don cututtukan huhu da urinary tract.
Halaye
Wannan samfurin yana da babban aikin antifungal akan Candida spp.da Candida spp.kuma yana da aikin antibacterial akan Bacillus spp.da kuma Mycobacterium spp.Samfurin yana da antibacterial a ƙananan taro da fungicidal a babban taro.Hanyar aikin shine don toshe kira na fungal nucleic acid.Naman gwari yana da sauƙi don samar da juriya ga wannan samfurin.
Matakan kariya
Haɗe tare da amphotericin B, yana da tasirin synergistic, amma yana iya rage fitar da wannan samfurin daga koda kuma yana ƙara yawan ƙwayar jini, wanda zai iya haifar da halayen guba a cikin koda da tsarin jini.Sabili da haka, ya kamata a kula da ƙwayar jini mafi girma kuma a kiyaye shi a 50-75μg / ml, bai wuce 100μg / ml ba;Yin amfani da masu hana kasusuwa na kasusuwa na iya ƙara yawan guba na hematologic na wannan samfurin.
Wannan samfurin zai iya haifar da ① tashin zuciya, zawo, kurji, da dai sauransu;② lalacewar hanta, yawancin alamun aikin hanta masu girma, amma har da hepatomegaly ko ma hepatic necrosis;③ myelosuppression leukocyte da raguwar platelet, lokaci-lokaci na iya haifar da cytopenia duka jini.An kuma bayar da rahoton rashi na granulocytic leukocyte mai kisa da anemia remitting;An kuma bayar da rahoton hallucinations, ciwon kai da vertigo.Don haka, yi amfani da taka tsantsan a cikin marasa lafiya masu ciwon hanta ko na koda, rashin lafiyar jini, da maƙarƙashiyar ƙashi.Hoton na gefe, aikin hanta da koda da fitsari yakamata a duba akai-akai lokacin amfani da wannan samfur.Yana da tasirin teratogenic a gwajin dabbobi, kuma yakamata a yi amfani da shi da hankali a cikin mata masu juna biyu.
Abubuwan da ba su da kyau sun haɗa da haɓakar transaminases, alkaline phosphatase, alamun gastrointestinal, leukopenia, anemia, thrombocytopenia, nakasa na koda, ciwon kai, raguwar hangen nesa, hallucinations, asarar ji, dyskinesia, rage ƙwayar potassium, ƙimar calcium da phosphorus, da rashin lafiyan halayen (misali rash). .
