Kayayyaki
Bucladesine
Tsarin Tsari
Abubuwan Jiki
Bayyanar: Farin ɗanyen samfur
Yanayin ajiya: -20°C
Solubility H2O: 50 mg/ml
Bayanan Tsaro
Na kayan gama gari ne
Aikace-aikace
Dibutyryl cyclic adenosine monophosphate sodium wani nau'i ne na adenosine monophosphate na cyclic, wanda ake amfani dashi don magance girgizar zuciya da ciwon zuciya.A cikin 1999, an samar da maganin shafawa na Dibutyryl cyclic adenosine monophosphate sodium don magance cututtukan fata da gyambon fata.
Shiri na sodium dibutyryl cyclophosphate adenosine: A cikin flask dauke da cyclophosphate adenosine sannu a hankali ƙara ruwa mai ruwa sodium hydroxide bayani (3 mol / L) dropwise, tsarin sarrafa zafin jiki, dropwise gama warming zuwa dakin zafin jiki, daidaita pH zuwa 7 ~ 8 tare da HCl bayani ( 20%), ƙara anhydrous ethanol hazo na farin m, tacewa, bushewa don samun farin m sodium gishiri;gishirin sodium da n-butyl anhydride a ƙarƙashin kariya na N2 warming zuwa 140 ℃ dauki.TLC saka idanu, da dauki ya cika sa'an nan saukar da zuwa dakin zafin jiki, sannu a hankali ƙara methyl tert-butyl ether, da tsari na karfi stirring, Chemicalbook don samun kusan farin m samfurin.An sake dakatar da cakuda methyl tert-butyl ether da acetone don samun samfurin foda mai fari.Ayyukan HalittuDibutyryl-cAMP (Bucladesine, dbcAMP) mai kunnawa PKA ce mai iya jujjuya tantanin halitta wanda ke aiki ta hanyar kwaikwayi cAMP na endogenous.
Nazarin in vitro: Dibutyryl-cAMP yana hana ɗaukar glucose na neuronal ta hanyar kunna PKA.A cikin al'adar hepatocytes na bera, Dibutyryl-cAMP yana hana inducible nitric oxide synthase magana da NF-kappaB ɗaurin aiki.dibutyrChemicalbookyl-cAMP kuma yana hana apoptosis da aka haifar da TNFalpha ta hanyar hana haɓakar FADD.
A cikin nazarin vivo: A cikin ƙirar linzamin kwamfuta, Bucladesine (600nM / linzamin kwamfuta, ip) ya juyar da zinc chloride da gubar acetate ya haifar da lalacewar ƙwaƙwalwar ajiyar ƙwaƙwalwar ajiya.
