Kayayyaki
Dexamethasone
Tsarin Tsari
Na zahiri
Bayyanar: farin foda
Yawan: 1.1283
Matsakaicin narkewa: 262-264°C
Tushen tafasa: 568.2± 50.0°C
Bayanan Tsaro
Nau'in haɗari: Kayan gabaɗaya
Aikace-aikace
An fi amfani dashi don maganin kumburi da kuma maganin rashin lafiyan.Ya dace da cututtuka na rheumatoid da sauran cututtuka na collagen.
An fara haɗa Dexamethasone (DXMS) a cikin 1957 kuma an jera shi a cikin Ma'auni na Mahimman Magunguna na WHO a matsayin ɗaya daga cikin mahimman magunguna don tsarin lafiyar jama'a.
A ranar 16 ga Yuni, 2020, WHO ta ce sakamakon gwajin asibiti na farko a Burtaniya ya nuna cewa Dexamethasone na iya ceton rayuka a cikin marasa lafiya da ke fama da matsanancin ciwon huhu, tare da rage mace-mace da kusan kashi ɗaya bisa uku na marasa lafiya da ke da iska da kuma kusan kashi ɗaya cikin biyar na marasa lafiya. oxygen kawai.
Dexamethasone shine corticosteroid na roba wanda za'a iya amfani dashi don magance yanayi daban-daban, ciki har da cututtuka na rheumatic, wasu yanayi na fata, rashin lafiyar jiki mai tsanani, asma, cututtuka na huhu na huhu, laryngitis na adalci, edema na kwakwalwa, da yiwuwar a hade tare da maganin rigakafi a cikin marasa lafiya masu fama da rashin lafiya. tarin fuka.Tana da darajar ciki na C a Amurka, wanda ke buƙatar tantancewa cewa tasirin maganin ya fi illar da ke tattare da shi kafin a iya amfani da shi, da kuma kimar A a Australia, wanda ke nuna cewa ana amfani da shi ga mata masu juna biyu. da kuma cewa babu alamar cutar da tayi.
Pharmacological effects
Dexamethasone, wanda kuma aka sani da flumethasone, fluprednisolone, da dexamethasone, shine glucocorticoid.Abubuwan da ke cikinsa sun haɗa da hydrocortisone, prednisone, da dai sauransu. Abubuwan da ke cikin magunguna sune galibi anti-inflammatory, anti-toxic, anti-allergic and anti-rheumatic, kuma ana amfani dashi sosai a aikin asibiti.Plasma T1/2 shine mintuna 190 kuma nama T1/2 shine kwanaki 3.Matsakaicin mafi girman adadin dexamethasone sodium phosphate ko dexamethasone acetate yana kaiwa awanni l da awanni 8 bi da bi bayan allurar cikin tsoka.Adadin daurin furotin na plasma na wannan samfurin ya yi ƙasa da na sauran corticosteroids.Ayyukan anti-mai kumburi na 0.75 MG daidai yake da 5 MG na prednisolone.Adrenocorticosteroids, anti-inflammatory, anti-allergic da anti-mai guba sakamako sun fi karfi fiye da na prednisone, da kuma tasirin sodium riƙewa da potassium excretion ne sosai haske.
1. Tasirin ƙwayar cuta: Yana iya ragewa da hana amsawar nama zuwa kumburi, don haka rage bayyanar kumburi.Hormones suna hana tarin ƙwayoyin ƙwayoyin cuta, ciki har da macrophages da leukocytes, a wurin kumburi da hana phagocytosis, sakin enzymes na lysosomal, da kira da saki na masu shiga tsakani na kumburi.
2. Immunosuppressive effects: ciki har da hanawa ko hana amsawar rigakafi ta hanyar salula, jinkirin halayen rashin lafiyar jiki, rage yawan T lymphocytes, monocytes, da eosinophils, rage ikon dauri na immunoglobulins zuwa masu karɓa na sel, da hana haɗuwa da sakin interleukins. , don haka rage jujjuyawar T lymphocytes zuwa lymphoblasts da rage haɓakar haɓakar amsawar rigakafi na farko.Yana rage rarrabuwar kasusuwa na rigakafi ta cikin membrane na ginshiki kuma yana rage yawan abubuwan da suka dace da kuma immunoglobulins.
Ana ɗauka da sauri daga sashin GI, tare da plasma T1/2 na mintuna 190 da nama T1/2 na kwanaki 3.Ana kai yawan adadin jini a sa'a 1 da sa'o'i 8 bayan allurar intramuscular na dexamethasone sodium phosphate ko dexamethasone acetate, bi da bi.Adadin daurin furotin na plasma na wannan samfurin yana ƙasa da sauran corticosteroids, kuma aikin anti-mai kumburi na wannan samfurin 0.75 MG yayi daidai da 5 MG na prednisolone.
