Kayayyaki
Doxifluridine
Tsarin Tsari
Na zahiri
Bayyanar: White Solid
Maɗaukaki: 1.3751 (ƙididdiga)
Matsayin narkewa: 188-192 ° C (lit.)
Takamaiman Juyawa: d25 +18.4° (c = 0.419 Cikin Ruwa)
Refractivity: 20 ° (c=1, H2o)
Yanayin Ma'ajiya: Yanayi maras amfani, Zazzabin ɗaki
Factor Acidity (pka): 7.4 (a 25 ℃)
Bayanan Tsaro
Nau'in haɗari: Ba kayayyaki masu haɗari ba
safarar kayayyaki masu haɗari:
Nau'in marufi:
Aikace-aikace
1. A matsayin prodrug na 5-Flurouridine.A fluorinated pyrimidine nucleoside tare da aikin cytostatic.An yi amfani da shi na asibiti don ciwon daji na ciki, ciwon daji na colorectal, ciwon nono, yawan gafara zai iya kaiwa fiye da 30%
2. A matsayin matsakaici don Fluorouracil antitumor kwayoyi
Gabatarwa ga amfani
1. Fluorouracil na tushen antitumor jamiái ne precurors zuwa fluorouracil.Enzyme thymidine phosphorylase, wanda yake a cikin ƙwayar ƙwayar cuta, yana aiki da shi don canza shi zuwa fluorouracil a cikin ƙwayar cuta, don haka yana haifar da sakamako na anti-tumor.Yana da ƙaƙƙarfan ƙayyadaddun ƙayyadaddun ƙwayar cuta da ƙarancin guba.Ana amfani da shi a asibiti a cikin ciwon daji na ciki, ciwon daji na colorectal da kuma ciwon nono, tare da yawan gafara har zuwa 30% ko fiye.
2. Matsakaicin magunguna.
3. Yana da wakili na antitumor, precursor miyagun ƙwayoyi na fluorouracil (5-FU), wanda aka canza zuwa fluorouracil kyauta ta hanyar aikin pyrimidine nucleoside phosphorylase a cikin ƙwayoyin tumo, don haka ya hana biosynthesis na DNA da RNA a cikin ƙwayoyin tumor da kuma nuna ta. antitumor sakamako.Tunda ayyukan wannan enzyme ya fi girma a cikin kyallen takarda fiye da na al'ada.Ana amfani da shi wajen maganin ciwon daji na nono, ciki da dubura kuma yana da ƙarancin guba.
