Kayayyaki
3,3'- diindolylmethane
Bayani
3,3'-diindolylmethane shine matsakaicin magunguna;Ana iya samuwa a cikin phytochemicals na halitta na Cruciferae Plants, acid catalyzed dauki kayayyakin, indole-3-methanol;Yana da aikin wakili na anti-tumor;A karkashin yanayin da aka kwatanta da babban taro, abin da aka samo asali ba zai iya hanzarta hanzarta apoptosis na ƙwayoyin cutar kansar ɗan adam ba, amma kuma yana da hankali kan hanya don haifar da apoptosis na ƙwayoyin cutar kansa;MemyementimDimmentim ya haifar da zobar g1 a cikin sel McF-7 ta hanyar sanannun inji da kuma ɗaukakawa da magana da juna;Dim shine mai hana mitochondrial h + -atpase;A matsayin sabon mai haɓaka ci gaban shuka, an yi amfani da dim da abubuwan da suka samo asali a cikin binciken tsarin yanayin yanayi.
Bayanin samfur
Saukewa: 1968-05-4
Tsafta: ≥98%
Saukewa: C17H14N2
Formula Wt.Shafin: 246.31
Sunan Chemical: 3,3'-Diindolylmethane
Synonym: :3,3'-Diindolylmethane(DIM);Di(1H-indol-3-yl);Tsarin:Indole;3,3'-DIINDOLYLMETHANE,>=98%(HPLC);3,3'-METHYLENEBIS- 1H-INDOLE;3,3'-METHYLENEBISINDOLE;3,3'-METHYLENEDIINDOLE;3,3'-DIINDOLYLMETHANE
Wurin narkewa: 167 ° C
Wurin tafasa: 230 ° C
Solubility: Chloroform (Sparingly), methanol (dan kadan)
Bayyanar: Kashe-farar foda
Shipping da Adana
Kwanciyar ma'ajiyar da aka ba da shawarar zazzabi -20°C.
Shiri Place indole (1.17 g, 10 mmol), CTAB (50% mol) da oxalic acid (50% mol) a cikin 25 ml mai wuyan wuyansa zagaye-ƙasa, ƙara 5 ml na ruwa mai narkewa, motsawa sosai don 5 min sannan ƙara ruwa formaldehyde bayani (0.38 g bayani, 5 mmol formaldehyde) dropwise.Amsa na tsawon sa'o'i 3 a dakin da zafin jiki kuma dakatar da amsawa.An fitar da maganin dauki tare da 15 ml na ethyl acetate a cikin sassa uku, kuma an tattara tsarin kwayoyin halitta kuma an bushe shi da Na2SO4 mai anhydrous na 5 hours.An cire sauran ƙarfi a ƙarƙashin raguwar matsa lamba kuma an sake yin recrystallized daga cakuda methanol da ruwa (methanol/H2ChemicalbookO = 10/1) don ba da farin m 3,3'-diindolylmethane a cikin 85% yawan amfanin ƙasa.Bioactivity3,3'-Diindolylmethane (DIM) shine babban samfurin narkewa na indole-3-carbinol, wanda shine yiwuwar maganin ciwon daji a cikin kayan lambu na cruciferous.3,3'-Diindolylmethane (DIM) shine tsantsa mai karfi mai karfi na androgenreceptor (AR) .
Nazarin a cikin vitro ya nuna cewa DIM shine ingantaccen mai kariyar rediyo da mai ragewa, yin aiki ta hanyar ƙarfafa ATM-drive DDR-kamar martani da kuma NF-κB siginar rayuwa.DIM na iya hana mamaye ƙwayar ƙwayar cuta, angiogenesis, haɓakawa da haifar da apoptosis ta hanyar daidaita hanyoyin sigina. kamar AKT, NF-κB da FOXO3.Hakanan zai iya hana bayyanar cututtukan da ke haifar da isrogen da haifar da damuwa na endoplasmic reticulum.Littafin sinadaraiDIM na iya canza isrogen metabolism kuma yana adawa da isrogen da aikin mai karɓar isrogen.A cikin vivo binciken ya nuna cewa DIM yana da tasiri a kan radiation tsarin bayan gwamnatoci da yawa.A cikin gwaje-gwajen vivo, DIM ta ba da kariya ta radiation ko ragewa.A cikin kyallen takarda na al'ada, DIM yana kunna ATM.Ana iya ba da dIM ga mice ta hanyar cika baki (250 mg / kg) tare da babban bioavailability kuma babu m t.
