Kayayyaki
Polyinosinic acid-polycytidylic acid
Tsarin Tsari
Na zahiri
Bayyanar: fari ko kashe-fari foda
Yawan yawa.
Wurin narkewa.
Wurin tafasa.
Refractivity
Ma'anar walƙiya.
Bayanan Tsaro
Kashi mai haɗari.
Lambar safarar Kaya mai haɗari.
Kashi na shiryawa.
Aikace-aikace
An san Poly I: C don yin hulɗa tare da mai karɓa na 3 (TLR3), wanda aka bayyana a cikin endosomal membrane na B-cell, macrophages da dendritic sel.Poly I:C yana da tsari kama da RNA mai madauri biyu, wanda ke cikin wasu ƙwayoyin cuta kuma shine "na halitta" mai motsa rai na TLR3.Don haka, ana iya la'akari da Poly I:C analog na roba na RNA guda biyu kuma kayan aiki ne na yau da kullun don binciken kimiyya akan tsarin rigakafi.
Halaye
Wannan samfurin shine inducer interferon roba, wanda shine polyribonucleotide mai madauri biyu wanda ya ƙunshi polyinosinic acid da polycytidylic acid.Tunda interferon yana da takamaiman nau'in, yana da wahala a shirya adadi mai yawa don aikace-aikacen asibiti, don haka galibi ana amfani dashi azaman inducer interferon don haifar da interferon.Bugu da kari, polyinosinic acid har yanzu yana da rawar da adjuvant na rigakafi, wanda zai iya ta da reticuloendothelial tsarin, inganta phagocytic aiki na phagocytes, inganta samuwar rigakafi da tsarin, ta da allograft dauki da kuma jinkirta rashin lafiyan dauki.Yana da faffadan antiviral da antitumor effects.
Hanyoyin amfani da hadawa
Dubawa
Polycytidylic acid, wanda kuma aka sani da polyinosinic acid, polyhypoxanthine nucleotide da polycytidine nucleotide, yana daya daga cikin polynucleotides, wanda ya ƙunshi sarkar polynucleotide mai nau'i biyu na polyinosinic acid da polycytidylic acid, tare da halayen decolorization da narkewa, kuma barga a -20 ℃. .
Pharmacological effects
1. Polyinosinic acid yana da tasiri mai kyau na haɓakawa akan ƙayyadaddun ƙayyadaddun ƙayyadaddun rigakafi na jiki.
(1) Polymyocytes suna haɓaka aikin ƙwayoyin rigakafi
(2) Polymyocytes suna haɓaka fitar da ƙwayoyin cytokines daban-daban
(3) Shigar da furotin Mx ta hanyar polymyocytes
(4) Polymyocytes suna haɓaka samar da ƙwayoyin rigakafi a cikin vivo
2. Anti-viral sakamako na polymyocytes
Gwaje-gwajen in vitro, gwaje-gwajen dabbobi da gwaje-gwajen asibiti na ɗan adam sun tabbatar da cewa polymyxins suna da nau'ikan tasirin antiviral, gami da cutar zazzabin rawaya, ƙwayar cuta ta encephalomyelitis, cutar zazzabin Rift Valley, ƙwayar cutar mura, cutar hanta, cutar AIDS, ƙafa-da-baki. cuta cutar, conjunctivitis virus, sauki rash virus, Mengo virus, pox virus, myocarditis virus, Aleutian virus, coxsackievirus, da dai sauransu An tabbatar da cewa rigakafin rigakafin Polymyxa ne mafi alhẽri daga warkewa sakamako na cutar kamuwa da cuta.
Aikace-aikace
1.Homopolymer guda biyu wanda za'a iya amfani dashi azaman samfurin RNA don nazarin siginar kwayar halitta a matakin TLR3 yana gane RNA mai nau'i biyu, wanda kuma shine babban tasirin maganin rigakafi ga ƙwayoyin cuta.
2.Haɗa tare da polyinosinic acid don samar da kwayar halitta ta polyinosinic, ana amfani da ita don maganin cututtukan hanta, herpes zoster, herpes simplex keratitis, herpes stomatitis, annoba na hemorrhagic zazzabi, da dai sauransu.
3. Yana da tasirin rigakafi na rigakafi, yana ƙarfafa tsarin reticuloendothelial, yana haɓaka phagocytosis, yana haɓaka samuwar antibody, yana haɓaka halayen allograft da jinkirin rashin lafiyan.Yana yana da m-bakan antiviral sakamako da antitumor sakamako.An fi amfani da shi a asibiti don: rigakafi ko maganin cututtukan cututtuka, jiyya na herpes zoster, herpetic keratitis, hepatitis viral.Adjuvant maganin ciwace-ciwacen daji.Mummunan halayen sun haɗa da hypothermia na wucin gadi da kuma lokuta masu zafi sama da 38 ℃, wanda galibi yana raguwa da kansa a cikin kwanaki 1-2.Idan zazzabi bai kwanta a cikin kwanaki 2 ba, yakamata a daina maganin nan da nan.Hakanan ana ganin rauni, bushewar baki, tashin hankali, tashin zuciya da sauransu.
